cold Respiratory tract infection
Conditions
Interventions
None listed
Sponsors
Levels Diagnostics
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: RTI group (250 patients) -Mentally competent & adult, bacterial or viral respiratory tract infection) Controlgroup (50 patients): -Mentally competent & adult, patients without clinical signs of a respiratory tract infection
Exclusion criteria
Exclusion criteria: RTI group: Undefined (unable to determine and identify the pathogenic origin) respiratory tract infection. Control group: fever or other symptoms known to RTIs within 14 days prior to inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary study parameters The current experiment has been designed to identify biomarker signatures with discriminative differences as to the expression within the blood plasma of patients. The primary study parameter is the concentration of those specific biomarkers resulting in a concentration of protein per mL blood plasma. This will then be used in our machine learning analysis to form biomarker profiles capable of determining an acute bacterial respiratory tract infection. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters After the performance analysis of the biomarkers to determine an acute bacterial respiratory tract infection, the performance of these markers will be tested against a number of known covariants. These are the following: 1. Analysis of the performance of the biomarkers to identify disease severity (e.g. PSI/PORT scoring in CAP subpopulation or by CURB65/qSOFA categorizing; 2. Analysis of the performance of the biomarkers in selected pathogen groups; 3. Analysis of the performance of the biomarkers across multiple disease backgrounds; 4. Analysis of the performance of the biomarkers comparing patients who are pre-treated with antibiotics versus non pre-treated patients. | — |
Countries
Netherlands
Outcome results
None listed