Retraining the Fatigued Brain (REFAB): A randomized controlled trial evaluating personalized cognitive rehabilitation treatment in somatic symptom and related disorders

Retraining the Fatigued Brain (REFAB): A randomized controlled trial evaluating personalized cognitive rehabilitation treatment in somatic symptom and related disorders - REFAB

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON56516

Enrollment

150

Registered

2024-02-22

Start date

2024-08-09

Completion date

Unknown

Last updated

2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

persevering somatic complaints somatic symptom disorder somatoform disorder

Interventions

The experimental group will receive personalized cognitive rehabilitation treatment, whereas the control condition will receive treatment as usual (cognitive behavioral therapy).

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: - SSRD diagnosis - Subjective cognitive complaints - Age: 18 years or older

Exclusion criteria

Exclusion criteria: Acute psychosis Addiction that requires treatment first Insufficient mastery of the Dutch language Blindness, deafness Severe cognitive disorder (e.g. aphasia, dementia)

Design outcomes

Primary

Measure	Time frame
The main study parameter is the suspected change in subjective and objective cognitive functioning after the treatment, as measures using questionnaires and neuropsychological tests, respectively.	—

Secondary

Measure	Time frame
Secondary outcomes include (possible changes in) brain activity, stress system activity and immune system activity.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP) · Data processed: Jul 23, 2026