adenomyosis growth of inner lining uterus into uterine wall Contrast-enhanced ultrasound Microvasculature Gynaecology Uterine disorders
Conditions
Interventions
Contrast enhanced ultrasonography of the uterus
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - >18 years of age - Have a uterus - Signed Informed Consent
Exclusion criteria
Exclusion criteria: - Pregnant women - Known allergy to SonoVue or any of its components - Severe heart disease or recent onset of cardiac rhythm disorders - Severe pulmonary hypertension - Use of angiogenesis inhibitor
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood flow parameters (e.g. arrival time, peak intensity, wash-out time) obtained from time-intensity curves of adenomyosis, myomas and uteri without a disorder. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Blood flow parameters of sarcomas - CEUS enhancement characteristics (e.g. homogeneity, order of enhancement, echogenicity) of adenomyosis, fibroids, sarcoma and uteri without disorders - Diagnostic performance (sensitivity, specificity and diagnostic accuracy) of detecting uterine disorder based on: o CEUS classification model for adenomyosis o CEUS classification model for sarcomas o Conventional ultrasound (assessment of the gynecologist) o MRI (assessment of the radiologist) o Histology (assessment of the pathologist) o Combination of all diagnostic tests used in the patient, including clinical presentation (assessment of the gynecologist) | — |
Countries
Belgium, Netherlands
Contacts
Public ContactJ.A.F. Huirne
Amsterdam UMC
Outcome results
None listed