Diabetes mellitus type 2 type 2 diabetes Type 2 diabetes
Conditions
Interventions
N.A.
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: All subjects: • Age > 40 and younger than 70 years • Sex: male • Ability and willing to give informed consent • Ability to follow test instructions • Sufficient understanding of the Dutch language Healthy control subjects: • BMI: 20-25 kg/m2 Type 2 diabetes patients: • Patients diagnosed with type 2 diabetes for at least 1 year• Indicated for initiation of standard-of-care therapy with semaglutide, with no prior use of GLP-1 receptor agonists • BMI: 27-35 kg/m2
Exclusion criteria
Exclusion criteria: All subjects: • Contra-indications to MRI examination according to 7T MRI screening guideline of the UMC Utrecht • An average alcohol consumption of >21 standard drinks per week • Abnormal liver function (fibrosis) Type 2 diabetes patients: • Known causes of hepatic steatosis other than non-alcoholic fatty liver disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are 3D DMI measurements of hepatic carbohydrate of healthy volunteers and type 2 diabetes patients. Specifically we will determine rates of glucose uptake and metabolism. | — |
Countries
Netherlands
Contacts
Public ContactJ.J. Prompers
Universitair Medisch Centrum Utrecht
Outcome results
None listed