Endothelial colony forming cells and plasma for in vitro studies of thrombosis in the elderly

Endothelial colony forming cells and plasma for in vitro studies of thrombosis in the elderly - Endothelium and plasma in older patients with thrombosis/REPORT

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON56432

Enrollment

Registered

2023-12-20

Start date

2024-05-30

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

unwanted blood clotting venous thromboembolism

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: -patients/volunteers older than 60 years -diagnosis of VTE 1 year or longer before blood draw

Exclusion criteria

Exclusion criteria: -active cancer -symptomatic vascular disease, as defined by the use of platelet aggregation inhibitors -severe renal insufficiency (eGFR

Design outcomes

Primary

Measure	Time frame
-difference in expression of senescence markers in endothelial colony forming cells (ECFCs) from older individuals with versus without a previous unprovoked VTE.	—

Secondary

Measure	Time frame
-difference in abundance of 270 plasma proteins as measured with quantitative mass spectrometry between older individuals with or without a previous VTE -difference in thrombin generation capacity of endothelial colony forming cells (ECFCs) from older individuals with or without previous VTE in an organ on a chip model for thrombosis.	—

Countries

Netherlands

Outcome results