Breast cancer muscle
Conditions
Interventions
Caloric restriction:
The caloric restriction group will be subjected to a 30% reduction in daily
dietary energy intake (500-600 kcal per day) while maintaining the same
relative macronutrient intake
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1) Female 2) BMI 18.5-35.0 kg/m2 3) Diagnosed with breast cancer, with treatment requiring a lumpectomy
Exclusion criteria
Exclusion criteria: 1) Patients receiving preoperative chemo- or radio-therapy 2) >5% weight loss in the previous 6 months 3) Fasting glucose >7 mmol/L 4) Musculoskeletal injuries (which may interfere with performing the exercise program) 5) Participation in structured resistance exercise program 6) A history of neuromuscular problems 7) Use of anti-coagulants 8) Use of protein and/or fish-oil supplements 9) Participation in a 2H2O study in the previous 6 months
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Healthy breast tissue protein synthesis rates over the 7-day intervention period. Plasma concentrations of estrogen, insulin, growth hormone, IGF-1, IGFBP-1, IGFBP-3, C-reactive protein, IL-1, IL-6, TNF-alpha, IL-10. | — |
Primary
| Measure | Time frame |
|---|---|
| 1. Tumor tissue protein synthesis rates over the 7-day intervention period in breast cancer patients. 2. Muscle tissue protein synthesis rates over the 7-day intervention period in breast cancer patients. | — |
Countries
Netherlands
Outcome results
None listed