diabetes glucose metabolism
Conditions
Interventions
During the intervention period, 28 subjects will consume a potato-based dietary
pattern providing about 300 gr boiled potatoes daily. This will be compared
with a group of 28 subjects consuming a wh
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Men and women - Aged between 40-70 years - BMI between 25-35 kg/m2 (overweight and obese) - Serum total cholesterol = 8.0 mmol/L] according to the Standard for cardiovascular risk management of the Dutch general practitioners community [NHG]) - Serum triacylglycerol
Exclusion criteria
Exclusion criteria: - Allergy or intolerance to potatoes, pasta or rice - Serum total cholesterol >= 8.0 mmol/L - Serum triacylglycerol >= 4.52 mmol/L - Current smoker, or smoking cessation 3 kg in the past three months) - Use medication known to treat blood pressure, lipid or glucose metabolism - Use of an investigational product within another biomedical intervention trial within the previous 1-month - Severe medical conditions that might interfere with the study, such as epilepsy, asthma, kidney failure or renal insufficiency, chronic obstructive pulmonary disease, inflammatory bowel diseases, auto inflammatory diseases and rheumatoid arthritis - Active cardiovascular disease like congestive heart failure or cardiovascular event, such as an acute myocardial infarction or cerebrovascular accident - Not willing to give up being a blood donor from 8 weeks before the start of the study, during the study or for 4 weeks after completion of the study - Not or difficult to venipuncture as evidenced during the screening visit - Use of over-the-counter and prescribed medication or supplements, which may interfere with study measurements to be judged by the principal investigator; - Use of oral antibiotics in 40 days or less prior to the start of the study; - Blood donation in the past 3 months before the start of the study - Not willing to comply to study protocol during study or sign informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| In order to examine the impact of potato versus pasta / rice consumption on chronic glucose metabolism the primary outcome parameter of this study is a change in average daily glucose concentration measured over a 15 hours period between waking up and going to bed 7:00AM - 22:00PM for three consecutive days. | — |
Secondary
| Measure | Time frame |
|---|---|
| To investigate if potato consumption changes glucose metabolism, lipid metabolism and low-grade inflammation, general wellbeing, and vascular function. | — |
Countries
Netherlands
Outcome results
None listed