Acid-base disorder acidification of the blood
Conditions
Interventions
Randomized treatment with potassium chloride, potassium bicarbonate, potassium
gluconate, sodium chloride, sodium bicarbonate and placebo (6 x 5 days
treatment followed by 2 days wash-out, the salts
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Adult patients (above 18 years) with CKD stage 3b or 4 (44 - 15 ml/min/1.73 m2) Use of RAAS-inhibitors
Exclusion criteria
Exclusion criteria: - Use of any of the following drugs or supplements: mineralocorticoid receptor blockers, potassium-sparing diuretics, oral potassium binders, immunosuppressive medication, tolvaptan, acetazolamide, topiramate, sodium bicarbonate. Patients using double RAAS blockade (i.e., ACE-inhibitor + ARB). - Kidney transplant recipients - Patients with an active gastro-intestinal ulcer - Patients with previous history of ventricular cardiac arrhythmia - Patients with a life expectancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in plasma bicarbonate. | — |
Secondary
| Measure | Time frame |
|---|---|
| Effects on plasma potassium and chloride, acid-base parameters in urine and plasma, blood pressure and body weight. | — |
Countries
Netherlands
Outcome results
None listed