cognitieve stoornissen Insulin Resistance Syndrome Metabolic Syndrome Syndrome X
Conditions
Interventions
Study participants will receive in random order daily 60 g of skin roasted
peanuts (peanut intervention) or no peanuts for a total of 16 weeks (control
intervention), separated by a wash-out period
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Aged between 60-75 years - BMI between 20-35 kg/m2 - Fasting plasma glucose
Exclusion criteria
Exclusion criteria: - Allergy or intolerance to nuts - Left handedness - Current smoker, or smoking cessation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| At baseline, first anthropometric measurements will be performed and blood pressure will be determined. In addition, a fasting blood sample will be drawn. Another fasting blood sample will be drawn at eight weeks, while participants have to attend the research facilities to perform follow-up measurements after sixteen weeks. The primary endpoint is the difference at follow-up in the cerebral blood flow response before and after intranasal insulin administration between interventions. | — |
Secondary
| Measure | Time frame |
|---|---|
| Cognitive performance that will be assessed with a neuropsychological test battery is the secondary endpoint. | — |
Countries
Netherlands
Outcome results
None listed