Heavy water labeling of leukocytes in human skin and vet and additional cell populations in fat such as macrophages and adipocytes

Heavy water labeling of leukocytes in human skin and vet and additional cell populations in fat such as macrophages and adipocytes - HALLO (Heavy wAter Labeling of LeukOcytes in human skin)

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON56368

Enrollment

Registered

2020-12-03

Start date

2021-07-28

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

immunological defense in the skin skin immunity

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Excessive skin removal (body contouring, abdominoplasty), breast reduction surgery

Exclusion criteria

Exclusion criteria: Skin disease, chonische infectious disease, daily use immuno modulatory drugs

Design outcomes

Primary

Measure	Time frame
Production and loss rates ( lifespans) of different leukocyte subpopulations derived from healthy skin, fat and blood. Additional production and loss rates of different cell populations such as adipocytes and macrophages in fat.	—

Secondary

Measure	Time frame
Fraction of skin cells replaced by circulating blood leukocytes	—

Countries

Netherlands

Outcome results