Fysiologie van voedselverwerking. n.v.t.
Conditions
Interventions
After an overnight fast, participants will drink 750 mL of cow*s milk, a
plant-based milk low in protein or a plant-based milk high in protein. Gastric
content and coagulation will be monitored usin
Sponsors
Wageningen Universiteit
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Male Age between 18 and 45 years BMI between 18.5 and 25 kg/m2 Apparently healthy (self-reported) Willing to be informed about incidental findings of pathology and consenting to informing their general practitioner about this.
Exclusion criteria
Exclusion criteria: Allergy or intolerance for cow milk, lactose and/or gluten (self-reported) Gastric disorders or regular gastric complaints, for example heartburn Use of medication which alters the normal functioning of the stomach, such as: o Medical drug use that influences the GI tract's normal function, e.g. motility, pH etc.: among others use of protein pump inhibitors, antacids, anti-depressants etc. (judged by study doctor) o Medical drug use that influences the GI tract's microbiota: antibiotic use within one month prior to the pre-study screening day (judged by study doctor) Smoking (>2 cigarettes/week) Having a chronic illness that could affect food digestion and nutrient absorption including but not limited to kidney disease, thyroid disease and diabetes mellitus (self-reported) Alcohol consumption of more than 14 glasses/week Following a vegan diet Having a chronic illness that could affect food digestion and nutrient absorption including but not limited to kidney disease, thyroid disease and diabetes mellitus (self-reported). Having a contra-indication to MRI scanning, including, but not limited to: o Pacemakers and defibrillators o Intraorbital or intraocular metallic fragments o Ferromagnetic implants o Claustrophobia Having given blood donation in the past two months Hb value below 8.5 mmol/l Participating in other research during the study period Not having a general practitioner
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postprandial plasma amino acid profiles over time | — |
Secondary
| Measure | Time frame |
|---|---|
| Gastric protein coagulation (change from t=5 over time) Gastric content volume (mL) (amount over time) Time to peak amino acid concentration (min) Postprandial glucose and insulin (change in concentration from baseline over time) Postprandial FGF21 (amount over time) Appetite and wellbeing verbally rated on a scale from 0 to 100 MRI markers of digestion (MT, T2) | — |
Countries
Netherlands
Outcome results
None listed