Type 2 diabetes
Conditions
Interventions
None listed
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 40 participants with prediabetes (FPG 6.1-7.0mmol/l) who have provided consent to be informed about future research will be identified in the New Hoorn Study Cohort in the measurement of 2021-2023. 20 of them having more than 1 hour of social jetlag and 20 of them having less than 1 hour of social jetlag.
Exclusion criteria
Exclusion criteria: Excessive alcohol use (>14 alcoholic consumptions per week) Having crossed more than 1 time zone in the month prior to participation Working shifts more than once per month Unable to give written informed consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The first main outcome is glycaemic control, measured with fasting blood glucose levels, HbA1c levels, and 2h glucose levels after an oral glucose tolerance test, comparing those with and without social jetlag. | — |
Secondary
| Measure | Time frame |
|---|---|
| Additionally, to assess which factors mediate this association, we will assess physical activity, (para)sympathetic nervous systemactivity from ECGs and electrochemical skin conductance tests, the Dim Light Melatonin Onset (DLMO) in saliva samples, HPA-axisactivation from cortisol awakening reaction in saliva samples and visceral fat distribution.Physical activity and sleep times and phases will be measured using an activity tracker and a sleep measuring headband. Dietaryintake will be assessed from the central Hoorn Study visit (or the RISC of HOM study visit). | — |
Countries
Netherlands
Outcome results
None listed