Brain function in macro- and micro-networks - an ECoG/stereo-EEG and fMRI approach

Brain function in macro- and micro-networks - an ECoG/stereo-EEG and fMRI approach - Brain function in macro- and micro-networks

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON56331

Enrollment

117

Registered

2014-09-11

Start date

2014-10-27

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

primary objective 2: locked-in syndroom, primary objective 3: epilepsie NA

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Epilepsy patient (m/f) scheduled for implantation with ECoG grids (for ECoG population) or stereo-EEG electrodes (for stereo-EEG population) - 18 years or older

Exclusion criteria

Exclusion criteria: There are no exclusion criteria for the current study. If a patient fulfils the inclusion criteria and gives informed consent, he/she can be included in the study. If a subject does not qualify for 3T and/or 7T fMRI (because of e.g. unremovable metals in the body), or is not willing to perform one or both of these scans, he / she will be asked to contribute to the ECoG or stereo-EEG part of the study. If a patient has already performed a clinical fMRI scan, or when clinical fMRI tasks are combined with research fMRI tasks in the same session, we will evaluate whether it is possible to use the data of the clinical scan/tasks for this research, to avoid having to perform a new fMRI scan, or a repetition of the same tasks, to minimize burden. Whether or not this is possible will depend on, among others, the task battery performed clinically.

Design outcomes

Primary

Measure	Time frame
The end-points are described per primary objective: - Establishment and modeling (quantification) of the relationship between hemodynamic signals measured with fMRI and underlying neuronal activation patterns - The ability of patients to achieve high-dimensional BCI control - The correspondence between fMRI and ECS and between ECoG/stereo-EEG and ECS - Function-selective measures of network dynamics, i.e. connectivity, causality and spatiotemporal patterns	—

Measure

Time frame

The end-points are described per primary objective: - Establishment and modeling (quantification) of the relationship between hemodynamic signals measured with fMRI and underlying neuronal activation patterns - The ability of patients to achieve high-dimensional BCI control - The correspondence between fMRI and ECS and between ECoG/stereo-EEG and ECS - Function-selective measures of network dynamics, i.e. connectivity, causality and spatiotemporal patterns

—

Countries

Netherlands

Outcome results