The clinical validation of a dried blood spot method for immunosuppressive drugs and creatinine

The clinical validation of a dried blood spot method for immunosuppressive drugs and creatinine - VIDA study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON56304

Enrollment

260

Registered

2020-04-01

Start date

2020-04-06

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Transplantatie Concentrations of drugs in blood following transplantation

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: - Aged 18 and over - Able to understand written information and able to give informed consent - Treated with tacrolimus, everolimus, sirolimus and/or ciclosporin - Able and willing to undergo a finger prick for dried blood spot sampling - Able and willing to fill in a questionnaire

Exclusion criteria

Exclusion criteria: Unable to draw blood samples for study purposes

Design outcomes

Primary

Measure	Time frame
Correlation between the DBS concentrations and venous blood concentrations of immunosuppressive drugs and creatinine.	—

Secondary

Measure	Time frame
- Analyzing the differences in the measured concentrations in the dried blood spot made with blood obtained from venous sampling and capillary sampling. - Evaluating the need of a correction factor when measuring the hematocrit in the DBS samples - Analyzing the difference between the drug concentration in the microtainer and filtrate card, to investigate the influence of the filtrate card on the drug concentration	—

Measure

Time frame

- Analyzing the differences in the measured concentrations in the dried blood spot made with blood obtained from venous sampling and capillary sampling. - Evaluating the need of a correction factor when measuring the hematocrit in the DBS samples - Analyzing the difference between the drug concentration in the microtainer and filtrate card, to investigate the influence of the filtrate card on the drug concentration

—

Countries

Netherlands

Outcome results