Anemia Anemia
Conditions
Interventions
Restrictive RBC transfusion threshold: in case the Hb transfusion trigger of
7.0 g/dL (4.3 mmol/L) is reached, 1 RBC unit at a time will be transfused. The
aimed Hb target range of the restrictive/i
Sponsors
Amsterdam UMC
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: - Patient is aged 18 years or older; - Is receiving ECMO; - (Deferred) informed consent.
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: - Not expected to survive for 24 hours when assessed; - Inability to receive blood products; - (Known) decline to blood transfusions; - Aged younger than 18 years; - Extracorporeal carbon dioxide removal (ECCO2R) using low blood flow devices or pumpless devices - Received ECMO over 48h before screening for eligibility.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome parameter is 90-day all-cause mortality. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes include: 1) proportion of patients on ECMO exposed to allogeneic RBC transfusion; 2) RBC volume infused per patient during ECMO; 3) reasons for RBC transfusion other than Hb triggers; 4) transfusion reactions; 5) time on ECMO; 6) length of hospital- and ICU-stay; 7) in-ICU morbidity; 8) quality of life (QoL) at 3, 6, 9 and 12 months; 9) costs related to a) transfusion, b) transfusion-related sequelae, c) medical consumption (up to 12 months) and d) productivity loss (up to 12 months). | — |
Countries
Austria, Belgium, Netherlands, Sweden
Contacts
Public ContactA.P.J. Vlaar
Amsterdam UMC
Outcome results
None listed