The Muscle Quality Index: linking quantitative MRI to muscle function

The Muscle Quality Index: linking quantitative MRI to muscle function - Motion

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON56280

Enrollment

162

Registered

2023-01-18

Start date

2023-02-28

Completion date

Unknown

Last updated

2024-04-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

concerns study in healthy volunteers N/A

Interventions

None listed

Eligibility

Age

16 Years to 64 Years

Inclusion criteria

Inclusion criteria: • Age between 16 and 60 years old • BMI between 18 and 30 kg/m2

Exclusion criteria

Exclusion criteria: • History of neuromuscular disease • Contra-indications for undergoing an MRI scan (e.g. because of pacemaker, claustrophobia, metal implants, metal splinters in the eye) • Inability to lie supine for 60 minutes • Inability to perform knee extension or knee flexion • Contra-indications for physical exercise without prior consultation with a physician verified using the Physical Activity Readiness Questionnaire (PAR-Q).

Design outcomes

Primary

Measure	Time frame
The primary outcome measures are isometric and isokinetic muscle force and the obtained qMRI parameters: - Muscle fat fraction, muscle volume, muscle length, and muscle shape assessed with a Dixon sequence. - T2 relaxation time of muscle water (T2water) assessed with a multi-slice multi spin echo sequence. - Mean diffusivity, fractional anisotropy, estimated muscle fibre length, muscle pennation angle and physiological cross-sectional area assessed with a diffusion weighted sequence. Other study parameters are the potential confounders in qMRI, like age, body weight, height, and composition, daily-life activity levels, and smoking and drinking history.	—

Measure

Time frame

The primary outcome measures are isometric and isokinetic muscle force and the obtained qMRI parameters: - Muscle fat fraction, muscle volume, muscle length, and muscle shape assessed with a Dixon sequence. - T2 relaxation time of muscle water (T2water) assessed with a multi-slice multi spin echo sequence. - Mean diffusivity, fractional anisotropy, estimated muscle fibre length, muscle pennation angle and physiological cross-sectional area assessed with a diffusion weighted sequence. Other study parameters are the potential confounders in qMRI, like age, body weight, height, and composition, daily-life activity levels, and smoking and drinking history.

—

Secondary

Measure	Time frame
n.a.	—

Countries

Netherlands

Outcome results