Expression of hSPCA1 and ultrastructural analysis of the skin before and after laser therapy in Hailey-Hailey disease

Expression of hSPCA1 and ultrastructural analysis of the skin before and after laser therapy in Hailey-Hailey disease - M. Hailey-Hailey: hSPCA1 expression and skin structure upon laser therapy

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON56274

Enrollment

Registered

2018-12-21

Start date

2019-01-31

Completion date

Unknown

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

acantholytic dermatosis bullous dermatosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Clinically diagnosed M. Hailey-Hailey as confirmed by histopathology and/or genetic analysis. - Indication for ablative laser therapy - >18 years old - Informed consent

Exclusion criteria

Exclusion criteria: -

Design outcomes

Primary

Measure	Time frame
Expression of the hSPCA1 calcium pump in keratinocytes before and after ablative treatment.	—

Secondary

Measure	Time frame
- Ultrastructure of the skin before and after ablative treatment. - Expression and localization of desmosomal proteins before and after ablative therapy. - Comparison of electron microscopy findings with those in subjects without M. Hailey-Hailey.	—

Countries

Netherlands

Outcome results