Evaluating kinetics and bioavailability of Aronia Melanocarpa extract in healthy young and older adults

Evaluating kinetics and bioavailability of Aronia Melanocarpa extract in healthy young and older adults - Bioavailability of Aronia Melanocarpa (BAM)

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON56259

Enrollment

Registered

2023-12-27

Start date

2024-03-25

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

farmacokinetiek absorption bioavailability pharmacokinetics

Interventions

During the test day, participants will ingest a drink consisting of 65 mg AME (16 mg anthocyanins), and 200 ml water.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: • Men and women, aged between 18-35 years, or between 55-75 years old • BMI between 18-35 kg/m2 • Systolic blood pressure

Exclusion criteria

Exclusion criteria: • Smoking or smoking cessation

Design outcomes

Primary

Measure	Time frame
The bioavailability and pharmacokinetics of AME will be assessed via frequent blood sampling, urine collection, and faecal sampling, in which AME and metabolite profiles will be quantified. Blood samples will be collected at t=0h, t=0.5h, t=1h, t=1.5h t=2h, t=2.5h, t=3h, t=4h, t=6h, t=8h, t=10h, t=12h, t=24h, t=48h following AME intake. Urine samples will be collected at t=0h, and in 6 different time intervals, i.e. t=0-4h, t=4-8h, t=8-12h, t=12-16h, t=16-24h, and t=24h-48h. Available faecal samples will be collected and combined into one sample until t=48h on a voluntary basis.	—

Measure

Time frame

The bioavailability and pharmacokinetics of AME will be assessed via frequent blood sampling, urine collection, and faecal sampling, in which AME and metabolite profiles will be quantified. Blood samples will be collected at t=0h, t=0.5h, t=1h, t=1.5h t=2h, t=2.5h, t=3h, t=4h, t=6h, t=8h, t=10h, t=12h, t=24h, t=48h following AME intake. Urine samples will be collected at t=0h, and in 6 different time intervals, i.e. t=0-4h, t=4-8h, t=8-12h, t=12-16h, t=16-24h, and t=24h-48h. Available faecal samples will be collected and combined into one sample until t=48h on a voluntary basis.

—

Secondary

Measure	Time frame
n.a.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP) · Data processed: May 1, 2026