Elucidating the high cardiovascular disease risk in South Asians: focus on monocyte phenotype and incretin hormones

Elucidating the high cardiovascular disease risk in South Asians: focus on monocyte phenotype and incretin hormones - CAMI study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON56245

Enrollment

Registered

2022-10-12

Start date

2023-06-26

Completion date

Unknown

Last updated

2026-04-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cardiovascular diseases cardiovascular diseases

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: - Males and females of South Asian or Dutch European ethnicity - Age from 18 to 30 years old - BMI 18 - 25 kg/m2 - Capable of giving informed consent

Exclusion criteria

Exclusion criteria: - (auto-) immune disease(s) including type 1 or 2 diabetes mellitus, chronic kidney disease, hepatic disease, inflammatory bowel disease, thyroid disease and rheumatoid arthritis. - Genetic lipid-associated disorders such as familial hypercholesterolemia - Any chronic renal or hepatic disease - Use of medication known to influence glucose and/or lipid metabolism (e.g. beta-blockers, antidepressants, corticosteroids) - Abuse of alcohol or other substances - Smoking - Vigorous exercise (>3 times/week) - Milk or soy allergy - Contrainindications for the InBody720 scan, such as a pacemaker - Participation in an intensive weight loss program or vigorous exercise program during the last year before the start of the study - laboratory abnormalities that could point towards an underlying disease

Design outcomes

Primary

Measure	Time frame
1. To compare immune cell composition between lean adolescent Dutch South Asian and BMI- and age-matched Dutch Europids 2. To compare the monocyte phenotype between lean adolescent Dutch South Asian and BMI and age-matched Dutch Europids 3. To compare functional and metabolic characteristics of monocytes between lean adolescent Dutch South Asian and BMI- and age-matched Dutch Europids	—

Secondary

Measure	Time frame
4. To compare glucocorticoid receptor sensitivity between lean adolescent Dutch South Asian and BMI- and age-matched Dutch Europids 5. To compare the release of incretins (GLP-1 and GIP) during a mixed meal tolerance test (MMTT) between lean adolescent Dutch South Asian and BMI- and age-matched Dutch Europids 6. To compare markers of glucose metabolism (glucose, insulin, C-peptide) during an MMTT between lean adolescent Dutch South Asian and BMI- and age-matched Dutch Europids 7. To compare markers of lipid metabolism (free fatty acids (FFA), triglycerides (TG), high-density-lipoprotein (HDL), total cholesterol) during an MMTT between lean adolescent Dutch South Asian and BMI- and age-matched Dutch Europids	—

Measure

Time frame

4. To compare glucocorticoid receptor sensitivity between lean adolescent Dutch South Asian and BMI- and age-matched Dutch Europids 5. To compare the release of incretins (GLP-1 and GIP) during a mixed meal tolerance test (MMTT) between lean adolescent Dutch South Asian and BMI- and age-matched Dutch Europids 6. To compare markers of glucose metabolism (glucose, insulin, C-peptide) during an MMTT between lean adolescent Dutch South Asian and BMI- and age-matched Dutch Europids 7. To compare markers of lipid metabolism (free fatty acids (FFA), triglycerides (TG), high-density-lipoprotein (HDL), total cholesterol) during an MMTT between lean adolescent Dutch South Asian and BMI- and age-matched Dutch Europids

—

Countries

Netherlands

Contacts

Public ContactMR Boon

Universiteit Leiden

m.r.boon@lumc.nl0648126425

Outcome results