allergic asthma asthma
Conditions
Interventions
The intervention group will receive soft chews containing 0.5g plant stanols
each (present as plant stanol esters) and are required to take six chews daily
(two after each main meal) in order to rea
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Having allergic asthma (step 1-4 according to GINA 2019 guidelines), stable at the moment of inclusion - Have been treated with low or medium dose inhalation corticosteroids in combination with a SABA or LABA, or as-needed low dose ICS-formoterol, or appropriate alternative medication according to the GINA guidelines for at least one year - Aged 18-70 - BMI between 20 and 35 kg/m2 - Willing to abstain from products containing plant sterols and/or stanols one month before and during the study - Willing to keep the intake of fish oil supplements constant during the study
Exclusion criteria
Exclusion criteria: - Currently smoking or quitted smoking in the past year, with a maximum of 10 packyears as smoking history (packyears = packs per day * years of smoking) - Allergy to an ingredient of the soft chews - Treatment with HMG-CoA reductase inhibitors (statins) to lower serum cholesterol - Suffering from inflammatory diseases (for CVD, illness must be minimally 3 years ago and currently under control in order to participate in the study) - Fasting plasma glucose > 7.0 mmol/L - Fasting serum TC > 8.0 mmol/L - Having donated blood within one month prior to the start of the study, or planning to donate blood during the study - Pregnant women - Breastfeeding women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study endpoint is the change in asthma control questionnaire (ACQ) score from baseline to the end of the study. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints include lung function parameters, markers for immune function, medication use, CVD risk parameters and vaccination response. | — |
Countries
Netherlands
Outcome results
None listed