Seasonal assessment of existing immunity for respiratory viruses in healthy volunteers to facilitate targeted vaccine development - a preparatory study

Seasonal assessment of existing immunity for respiratory viruses in healthy volunteers to facilitate targeted vaccine development - a preparatory study - Respiratory virus background immunity assessment

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON56235

Enrollment

3500

Registered

2023-09-22

Start date

2023-10-16

Completion date

Unknown

Last updated

2024-11-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

respiratory tract infections viral infection

Interventions

None listed

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: 1. Age 18-75 years and in good health; the upper age limit could be lowered for different executions of this protocol, but will never exceed 75 years. 2. Good health, based upon the results of medical history. 3. Subject has signed informed consent.

Exclusion criteria

Exclusion criteria: 1. Evidence of immunodeficiency in medical history 2. Prior use of immunosuppressive medication (systemic glucocorticoids six months prior to inclusion or any other systemic immunosuppressive medication at any time), immunoglobulins or systemic antiviral therapy)

Design outcomes

Primary

Measure	Time frame
To assess existing background immunity for respiratory virus stems in the general population using laboratory assessments containing, but not limited to: • Hemagglutination inhibiton assay (HAI) titre for selected viral stems, for Influenza • Microneutralization assay (MN) titre for selected viral stems • (Neutralizing) IgG & IgA titre for selected viral stems	—

Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results