Alzheimers disease cognitive decline dementia memory problems
Conditions
Interventions
 
Sponsors
Maastricht Universitair Medisch Centrum +
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Written informed consent obtained and documented Capable of giving informed consent themselves (MMSE score > 17/30)*
Exclusion criteria
Exclusion criteria: Ocular conditions that could influence tear biochemical parameters (including eye infection, eye inflammation, eye surgery within the last 28 days or other acute eye conditions) Neurological or systemic chronic conditions known to interfere with retinal thickness (e.g., glaucoma, diabetes mellitus) Ocular conditions interfering with OCT quality/retinal thickness: e.g. severe cataract, age-related macular degeneration, and glaucoma
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the difference in level of tear biomarkers (such as amyloid-beta and tau) between patients and controls, and between patient groups. | — |
Secondary
| Measure | Time frame |
|---|---|
| The correlation between tear biomarkers with CSF and blood biomarkers. The correlation between tear biomarkers and other ocular imaging biomarkers | — |
Countries
Netherlands
Contacts
Public ContactM Gijs
Maastricht Universitair Medisch Centrum +
Outcome results
None listed