headache migraine
Conditions
Interventions
None listed
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Patients with chronic migraine with medication overuse: i) age between 18 and 75 years; ii) able to provide written informed consent; iii) diagnosed with chronic migraine and medication overuse according to ICHD 3-beta criteria. , Patients with chronic migraine without medication overuse: i) age between 18 and 75 years; ii) able to provide written informed consent; iii) diagnosed with chronic migraine according to ICHD 3-beta criteria. , Patients with episodic migraine: i) age between 18 and 75 years; ii) able to provide written informed consent; iii) diagnosed with migraine with or without aura according to ICHD 3-beta criteria;
Exclusion criteria
Exclusion criteria: Patients with chronic migraine with medication overuse: i) Other primary or secondary headache syndromes except tension type headache or medication overuse headache Patients with chronic migraine without medication overuse: i) Other primary or secondary headache syndromes except tension type headache Patients with episodic migraine: i) Other primary or secondary headache syndromes except tension type headache (ii) A history of chronic migraine according to IHS 3-β criteria 40 mg/daily), clomipramine, dosulepin, doxepin, imipramine, nortriptyline, maprotiline), SNRIs (a.o. high dose duloxetine / venlafaxine, trazodone), or calcium channel inhibitors (a.o. pregabalin, gabapentin) in the past three months. (vii) Current abuse or history of abuse of alcohol, soft drugs or hard drugs, which in the opinion of the investigators may interfere with the study; (viii) Pregnancy or lactation; (ix) Enrolment in other studies that may confound the results of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Part A and part B Primary outcome measurements for of the three aspects: i) relative change in peak VAS score; ii) QST parameters; iii) corneal nerve fiber density. & Headache frequency | — |
Secondary
| Measure | Time frame |
|---|---|
| Part A and B Secondary outcomes for each of the three aspects: i) change in area under the curve (VAS*sec) of the test stimulus during the conditioned stimulus; ii) no additional outcomes; iii) corneal nerve fiber length and corneal nerve branch density. Additional outcome measures: - Sum scores on depression, anxiety and visual sensitivity questionnaires. | — |
Countries
Netherlands
Outcome results
None listed