scleroderma Systemic sclerosis
Conditions
Interventions
None listed
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: Patients diagnosed with SSc with the ACR-EULAR 2013 classification criteria, with scleroderma on the forearm. All participants needs to be 18-80 years of age and able and willing to complete the informed consent process.
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: Participants with an active inflammatory or infectious co-morbid disease will be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study endpoint is evaluation of anti-fibrotic/anti-SSc therapies using patient-specific SSc OoC models. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters include the development of an SSc in vitro model that incorporates key disease features, the investigation of patient-specific disease signatures and assessment of signalling pathways. | — |
Countries
Netherlands
Outcome results
None listed