infertility Subfertility
Conditions
Interventions
None listed
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: Repeated implantation failure - Female aged 18-38 years old - Repeated implantation failure (RIF) defined as: - failure of implantation of three high quality embryo*s or after placement of ten or more embryo*s in multiple transfers - Primary or secondary infertility - Written informed consent Recurrent miscarriages - Female aged 18-38 years old - Repeated, unexplained miscarriages (RM) defined as 2 or more unexplained miscarriages not caused by abnormal parental karyotype, maternal thrombophilia and/or uterine abnormalities - Written informed consent Control - Female aged 18-38 years old - Uneventful previous pregnancy defined as no preterm delivery, pre-eclampsia or fetal growth restriction and live birth OR presumed fertile defined as an indication for PESA/TESE, female sterilisation, or PGD indication for genetic analysis without subfertility treatment - Written informed consent
Exclusion criteria
Exclusion criteria: Repeated implantation failure - Clinically relevant intra-uterine pathology - BMI > 35 kg/m2 - Untreated endocrine abnormalities - PGD treatment Recurrent miscarriages - Current or recent ( 35 kg/m2 Control group - Recurrent miscarriages or repeated implantation failure - Current or recent ( 35 kg/m2 - Severe endometriosis (3th -4th degree)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are steroid profile in endometrial tissue and serum, activity of steroid enzymes, phenotype and function of Natural Killer cells, presence of HLA antibodies, determination of the vaginal microbiome and volatile organic compounds. | — |
Countries
Netherlands
Outcome results
None listed