arterial stenosis, atherosclerosis
Conditions
Interventions
 
Sponsors
Haaglanden Medisch Centrum (HMC)
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: - Patients undergoing endarterectomy surgery - Patients who are older than 18 years - Patients able to give their consent to enter the study - Patients who have signed an informed consent and the agreement form.
Exclusion criteria
Exclusion criteria: - Patients younger than 18 years old - Patients who are not able to give their consent to enter the study - Patients who have not signed an informed consent and the agreement form. - Patients that have already had an endarterectomy previously and are undergoing a redo of this surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary objective of this study is to measure the number of antigen specific T-cells in the plaque and in blood, and investigate whether these parameters correlate with the phenotype of the atherosclerotic plaque. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary objectives are: 1) To investigate the inflammatory status of other immune cells (dendritic cells, macrophages, mast cells, etc) in atherosclerosis by flow cytometry and gene expression analysis. 2) To correlate plaque phenotype to CT-angiography plaque characteristics. 3) To investigate whether gender has an effect on these T-cells and other immune cell subsets and plaque phenotype. | — |
Countries
Netherlands
Contacts
Public ContactI. Bot
Universiteit Leiden
Outcome results
None listed