Trial readiness and fitness for congenital myopathies: A 2-year prospective natural history study including a cross-sectional study on muscle fatigability

Trial readiness and fitness for congenital myopathies: A 2-year prospective natural history study including a cross-sectional study on muscle fatigability - READYCOM

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON56064

Enrollment

100

Registered

2023-08-07

Start date

2024-03-28

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Congenital myopathies Inherited muscle disorders

Interventions

Non therapeutical intervention

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: Genetically-confirmed congenital myopathy (core myopathy, nemaline myopathy, and centronuclear myopathy)

Exclusion criteria

Exclusion criteria: Other neuromuscular, psychiatric or neurological disorders

Design outcomes

Primary

Measure	Time frame
-Motor function measure -Endurance shuttle test	—

Secondary

Measure	Time frame
-Manual muscle testing -Isometric dynamometry -Range of motion -Respiratory muscle function measured by spirometry -Graded and timed rise from floor -6 MWT -7-day accelerometry -Vignos and Brooke scale -Laboratory tests -Muscle ultrasound -Muscle MRI -DEXA scan -Questionnaires -Isokinetic dynamometry -Repetitive nerve stimulation	—

Countries

Netherlands

Contacts

Public ContactN. Voermans

Radboud Universitair Medisch Centrum

nicol.voermans@radboudumc.nl+31650155770

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP) · Data processed: May 1, 2026