Nontuberculous mycobacterial cervicofacial lymphadenitis/Atypical mycobacterial head and neck infcection of the lymph nodes
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
No minimum to 15 Years
Inclusion criteria
Inclusion criteria: Study group: • Age between 0-15 years • High clinical suspicion of NTM cervicofacial lymphadenitis, as defined by the following factors; - Cervicofacial lymphadenopathy for a period longer than 3 weeks - Typical clinical presentation as defined by Penn et al. (2011) - Negative serologic tests for other kinds of (sub) chronical lymphadenopathy: Epstein-Barr virus, cytomegalovirus, Bartonella species, Adenovirus, and toxoplasmosis - Ultrasonographically, hypoechoic lymph nodes, often with central necrosis, nodal matting and adjacent soft tissue oedema Control group: • Age between 0-15 years • Indication for surgery under general anesthesia
Exclusion criteria
Exclusion criteria: Study group: - Known immunodeficiencies - Usage of immunosuppressive drugs Control group: - Clinical suspicion of NTM cervicofacial lymphadenisis as defined above
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sensitivity and specificity of the Capilia mac antibody Elisa test in patients with a clinical suspicion for NTM cervicofacial lymphadenitis. A receiver operating characteristic curve will be constructed and the overall accuracy will be expressed by the area under the curve. | — |
Secondary
| Measure | Time frame |
|---|---|
| The assessment of microbial composition and identification of NTM in the oral cavity, nose, oropharynx and excised lymph node material. | — |
Countries
Netherlands
Outcome results
None listed