neurodegenerative disorders, dementia Alzheimer's dementia memory loss
Conditions
Interventions
One intervention session using transcranial direct current stimulation (tDCS)
with a simultaneous MEG recording.
Sponsors
Vrije Universiteit Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: fulfilling the diagnostic criteria for probable AD; between 50-80 years of age; known amyloid status. Additionally, a signed informed consent for Amsterdam Dementia Cohort (ADC) (P2016.061) or AHR (P2016.409) is required.
Exclusion criteria
Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study: cardiac pacemakers, ICD's and other intracorporeal devices or medication interfering with MEG-signals; severe claustrophobia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study endpoint consists of MEG-based measures of oscillatory brain activity, functional connectivity and network topology, which indicate the degree of disruption or improvement in brain functioning. | — |
Secondary
| Measure | Time frame |
|---|---|
| Optimal stimulation parameters as determined by the model, and working memory scores. | — |
Countries
Netherlands
Outcome results
None listed