Skeletspier aandoeningen muscle mass muscle protein synthesis Sarcopenia
Conditions
Interventions
Participants will, in a randomized order, be assigned to 1 week of
resistance-type exercise training and protein supplementation and 1 week of
continuing their habitual lifestyle.
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. In order to be eligible to participate in this study, a patient with CKD must meet all of the following criteria: • (e)glomerular filtration rate (GFR) 60 ml/min//1.73m2 without albuminuria • Age: 18 - 80 y • Able to provide written informed consent
Exclusion criteria
Exclusion criteria: • Insulin-dependent diabetes mellitus or two or more oral glucose lowering medications • Active inflammatory disease / malignancies • Uncontrolled hypertension (>160/100mm Hg), unstable angina pectoris, or arrhythmia • Pulmonary disease restricting exercise performance (e.g. COPD) • A history of neuromuscular problems • Cognitive Impairment • Diagnosed GI tract diseases / dysphagia • Allergies to milk proteins / Lactose intolerance • Pregnancy • Hospitalization
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcomes in this study will be daily muscle protein synthesis rates as measured by the deuterated water method. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters include muscle mitochondrial bioenergetics, muscle fiber size, leg lean mass, and aerobic capacity muscle mitochondrial bioenergetics, saliva 2H enrichment, food intake, and physical activity levels.at baseline. | — |
Countries
Netherlands
Outcome results
None listed