Exercise training in women with unexplained recurrent pregnancy loss to optimize receptive endometrial NK cell population and function

Exercise training in women with unexplained recurrent pregnancy loss to optimize receptive endometrial NK cell population and function - HMove

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON55979

Enrollment

100

Registered

2021-10-19

Start date

2022-03-21

Completion date

Unknown

Last updated

2026-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

reproductieve immunologie recurrent miscarriage Recurrent pregnancy losses

Interventions

Exercise training for 12 weeks.

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Women with two or more unexplained pregnancy losses, defined as women without  uterine abnormalities, antiphospholipid syndrome, thyroid abnormalities and  abnormal parental karyotyping if indicated according to international  guideline.  Couples should not be aiming to conceive during the time course of the exercise  intervention.   

Exclusion criteria

Exclusion criteria: -Age above 40 years -Use of immunosuppressive drugs, biological or antidepressants -Use of hormone conceptive  -HIV positivity -Current or recent (<2 weeks) symptomatic genital infection such as chlamydia,  gonorroa, or pelvic inflammatory disease -Pre-existent diabetes mellitus, autoimmune disease or overt cardiovascular  disease  -Smoking or use of medication or supplements that might affect the  cardiovascular system -Vaccination (i.e Covid) within 3 months prior to or during sampling and  intervention -New pregnancy at time of measurements, breastfeeding  -Current or recent (<3 months ago) pregnancy -Women with plans to become pregnant during the course of intervention  -(Physical) inabilities to follow moderate aerobe cycling training -Participants who are not capable of signing the informed consent

Design outcomes

Primary

Measure	Time frame
CD56bright NK cell population and function in endometrium and peripheral blood in women with reduced endometrial NK cells (<80%).	—

Secondary

Measure	Time frame
Frequency and function of (CD56bright) eNK cells compared to baseline in women with unexplained RPL and more than 80% of eNK cells. General immune assessment of all samples (<80% and >80% eNK cells) for peripheral NK cells (before and after 12 weeks of an aerobe exercise intervention) and endometrial NK cells (before, during and after 12 weeks of an aerobe exercise intervention) in the intervention group and time control group. Additional to the immunological effects we will study the effects of exercise training on the vaginal microbiota, on cardiovascular and metabolic parameters, on autonomic balance, on uterine blood flow and on physical fitness levels. One year after completion of the intervention, pregnancy rate and live birth rate will be assessed.	—

Measure

Time frame

Frequency and function of (CD56bright) eNK cells compared to baseline in women with unexplained RPL and more than 80% of eNK cells. General immune assessment of all samples (<80% and >80% eNK cells) for peripheral NK cells (before and after 12 weeks of an aerobe exercise intervention) and endometrial NK cells (before, during and after 12 weeks of an aerobe exercise intervention) in the intervention group and time control group. Additional to the immunological effects we will study the effects of exercise training on the vaginal microbiota, on cardiovascular and metabolic parameters, on autonomic balance, on uterine blood flow and on physical fitness levels. One year after completion of the intervention, pregnancy rate and live birth rate will be assessed.

—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP) · Data processed: Jun 11, 2026