Characterizing tissue protein synthesis rates of non-small cell lung carcinomas in lung cancer patients

Characterizing tissue protein synthesis rates of non-small cell lung carcinomas in lung cancer patients - LungMaas

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON55965

Enrollment

Registered

2022-09-26

Start date

2023-06-30

Completion date

Unknown

Last updated

2024-09-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

carcinoma Lung tumor

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18-85 years 2. Compos mentis 3. Suspected lung cancer, with treatment requiring a thoracotomy or VATS lobectomy 4. Provided written informed consent

Exclusion criteria

Exclusion criteria: 1. Neoadjuvant chemo- or radiotherapy in the past four weeks 2. Use of systemic steroids in the past four week 3. Insulin-dependent diabetes mellitus 4. Pregnancy

Design outcomes

Primary

Measure	Time frame
Lung tumor and healthy lung tissue protein synthesis rates, expressed as fractional synthesis rates (FSR, %/d), will be measured for 5 days prior to tumor resection.	—

Secondary

Measure	Time frame
The FSRs of NSCLCs will be compared between the different sizes classifications within the cTNM system. Furthermore, the FSRs of NSCLCs will be compared between the different subclassifications (i.e., adenocarcinomas, squamous cell carcinomas, and large cell carcinomas). In addition, correlation analysis will be conducted to determine whether tumor tissue protein synthesis rates are influenced by other patient characteristics (i.e., inflammation, lung function, smoking status, and smoking history). Other characterization measurements include hand grip strength, muscle protein synthesis rates, muscle size (cross-sectional area erector spinae and other muscles at L3), visceral and subcutaneous adipose tissue (VAT/SAT) at L3.	—

Measure

Time frame

The FSRs of NSCLCs will be compared between the different sizes classifications within the cTNM system. Furthermore, the FSRs of NSCLCs will be compared between the different subclassifications (i.e., adenocarcinomas, squamous cell carcinomas, and large cell carcinomas). In addition, correlation analysis will be conducted to determine whether tumor tissue protein synthesis rates are influenced by other patient characteristics (i.e., inflammation, lung function, smoking status, and smoking history). Other characterization measurements include hand grip strength, muscle protein synthesis rates, muscle size (cross-sectional area erector spinae and other muscles at L3), visceral and subcutaneous adipose tissue (VAT/SAT) at L3.

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Countries

Netherlands

Outcome results