Coagulation fibrinolysis
Conditions
Interventions
After induction of anesthesia, but before incision, study medication will be
administered. The intervention group will receive 2000mg tranexamic acid. The
placebo group will receive a NaCl 0.9% bolu
Sponsors
Maasstadziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Patients scheduled for burn excisional surgery - An expected blood loss of >=250ml based on the estimation by the performing surgeon on the basis of: (1) 2 % body surface area excision planned (100-200 cc / %TBSA, based on retrospective data from Burn Centre Rotterdam), (2) operation technique used (some techniques show more blood loss than others), (3) time after burn trauma (i.e. expected healing). - >=18 years
Exclusion criteria
Exclusion criteria: - Patients with a recorded coagulopathy in their history - Severe kidney failure (creatinine >500 umol/L) - Allergy for tranexamic acid - Acute venous-/arterial thrombosis (ongoing thrombosis). A history of thrombosis is NOT an exclusion criterion - Diffuse intravascular coagulation - Pregnancy - History of epilepsy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study endpoints are the volume of blood loss and the extend of fibrinolysis. | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood transfusion requirements: - Number of blood product transfused Hospital Mortality Length of stay Operation success: - Success of skin graft (percentage successful take) Cardiopulmonary complication (i.e. arterial embolism) Neurologic complications (i.e. stroke, conclusion) Strength of the blood cloth and fibrin-structures | — |
Countries
Netherlands
Outcome results
None listed