brain tumor glioblastoma
Conditions
Interventions
Four advanced MRI techniques (qBOLD, ASL, DSC and CEST) will be investigated in this research. These techniques provide information on various biological aspects. qBOLD in combination with ASL provide
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Written informed consent; Adults (18 years or older); Diagnosed with IDH-wildtype glioblastoma, as confirmed by pathology including molecular analysis post resection/biopsy; Referred to the outpatient clinic of the Dept. of Radiotherapy to undergo standard treatment with radiotherapy (30x2 Gy or 15x2.67 Gy or 10x3.4 Gy);
Exclusion criteria
Exclusion criteria: Contraindication for (3 Tesla) MRI; Contraindication for use of gadolinium-based contrast agent (e.g. subject having renal deficiency or known allergy); Referred for treatment of recurrent glioblastoma; Previous radiotherapy to the brain; Unable to give informed consent;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pattern of failure and dose to organs at risk by the radiotherapy plan based on the 1.5-cm CTV and the theoretical plan created with the CTVbio. | — |
Secondary
| Measure | Time frame |
|---|---|
| • The differences in tumor recurrence coverage and size between the CTVbio (based on all three aMRI-scans) and CTVs based on individual or other combinations of aMRI, i.e. based on two or one aMRI-scan(s). • The difference in mean and maximum signal intensity on the individual aMRI-scans between the tumor recurrence site and the contralateral normal-appearing white matter. | — |
Countries
Netherlands
Contacts
Public ContactA.M. Mendez Romero
Erasmus MC, Universitair Medisch Centrum Rotterdam
Outcome results
None listed