cognitief functioneren cognition
Conditions
Interventions
Participants will receive, in random order, daily 160 mg of an
anthocyanin-rich Aronia extract (containing 40 mg anthocyanins) or a placebo
for six weeks, separated by a 12-week wash-out.
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: men and women, age 55-75, BMI 25-35 kg/m2
Exclusion criteria
Exclusion criteria: smoking, diabetes mellitus, active cardiovascular disease, severe medical conditions, use of supplements or medication affecting main outcomes, contra-indications for MRI
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cerebral blood flow responses before and after intranasal insulin administration will be non-invasively quantified by MRI. | — |
Secondary
| Measure | Time frame |
|---|---|
| Furthermore, effects of AME on cognitive performance will be assessed. Exploratory outcomes are other potential mechanisms responsible for observed effects on cognitive function, and other perceivable benefits such as vascular improvements and metabolic markers. | — |
Countries
Netherlands
Outcome results
None listed