Non-invasive measurement of mitochondrial function in vivo (NIMFO) in septic patients

Non-invasive measurement of mitochondrial function in vivo (NIMFO) in septic patients - NIMFO

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON55883

Enrollment

Registered

2017-03-28

Start date

2017-11-13

Completion date

Unknown

Last updated

2025-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sepsis, COVID-19 COVID-19 sepsis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Intensive care patients: In order to be eligible to participate in this study, a subject must meet the following criteria: * 18-90 years of age * Admission to intensive care ward within 72 hours before inclusion Aged and gender matched healthy controls: * 18-90 years of age * No relevant comorbidities (ASA I/II) * Matched in age (±5 years) and gender to one of the participants in the COVID-19 group.

Exclusion criteria

Exclusion criteria: * Mentally disabled * Porphyria * Presence of mitochondrial disease Healthy controls group: * Presence of COVID-19/sepsis related complains or symptoms * Presence of COVID-19/sepsis symptoms or complains, or a positive COVID-19 test less than one month ago * COVID-19 vaccination less than two weeks ago

Design outcomes

Primary

Measure	Time frame
COMET; Mitochondrial function (ODR)	—

Secondary

Measure	Time frame
Cellular oxygen availability in skin (mitoPO2 in mmHg) Mitochondrial function in platelets Mitochondrial DNA in plasma as a marker of mitochondrial damage Microvasculair bloodflow measured by O2C Capillary refill time sternum Mitochondrial function in peripheral blood mononuclear cells	—

Countries

Netherlands

Outcome results