laryngeal cancer Laryngeal carcinoma
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Patients with a T3 or T4 laryngeal or hypopharyngeal cancer scheduled for total laryngectomy. - Age >= 18 years. - Informed consent.
Exclusion criteria
Exclusion criteria: - Patients with indications for primary radiotherapy. - Patients with contraindications for surgery. - Patients who meet exclusion criteria for MRI at 3T as defined in the protocols of the Radiology department. - Patients with contraindication for CT contrast administration as defined in the protocols of the Radiology department. - Patients with insulin dependent diabetes mellitus.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The accuracy of DW-MRI in determining the volume of the tumour. | — |
Secondary
| Measure | Time frame |
|---|---|
| The sensitivity (part of the tumour that is delineated) and positive predictive power (part of the delineated volume that is tumour) of DW-MRI based tumour delineation compared with values obtained using CT, PET and anatomical MR imaging. The microscopic extension of the tumour measured as the distance between the gross tumour volume and the most distant microscopic lesions in the histopathology. | — |
Countries
Netherlands
Outcome results
None listed