Functional Renal Hemodynamics in Patients with and without Renal Artery Stenosis 2

Functional Renal Hemodynamics in Patients with and without Renal Artery Stenosis 2 - HeRA 2 Study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON55815

Enrollment

Registered

2019-04-08

Start date

2019-07-30

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

atherosclerotic renal artery stenosis renovasculair disease secundaire hypertensie

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age > 18 Written informed consent Clinically and hemodynamically stable Clinical indication for a coronary, renal, or peripheral vascular angiography with or without percutaneous intervention.

Exclusion criteria

Exclusion criteria: Recent ST-segment elevation myocardial infarction ( II) Increased risk for contrast nephropathy defined as presence of renal impairment (eGFR

Design outcomes

Primary

Measure	Time frame
Dynamic range of renal blood flow, represented by the relative baseline flow, the ratio between the difference of baseline and minimal flow velocity and baseline flow velocity.	—

Secondary

Measure	Time frame
Renal flow reserve, relative minimal flow, renal fractional flow reserve, baseline and hyperemic renal stenosis resistance, baseline and hyperemic microvascular resistance, phase difference between pressure and flow in sympathetic band for autoregulation. In patients where offline renal perfusion analysis is possible: renal perfusion as area under the curve of contrast density over time and the renal flow reserve computed by perfusion angiography. Correlation of main study parameters with relevant clinical, biochemical and imaging parameters.	—

Measure

Time frame

Renal flow reserve, relative minimal flow, renal fractional flow reserve, baseline and hyperemic renal stenosis resistance, baseline and hyperemic microvascular resistance, phase difference between pressure and flow in sympathetic band for autoregulation. In patients where offline renal perfusion analysis is possible: renal perfusion as area under the curve of contrast density over time and the renal flow reserve computed by perfusion angiography. Correlation of main study parameters with relevant clinical, biochemical and imaging parameters.

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Countries

Netherlands

Outcome results