New optical techniques in interstitial lung disease

New optical techniques in interstitial lung disease - New optical techniques in ILD

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON55811

Enrollment

Registered

2019-11-18

Start date

2019-11-27

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Diffuse Parenchymal Lung disease Interstitial lung disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Interstitial lung disease patients with an indication for lung tissue sampling

Exclusion criteria

Exclusion criteria: * Inability and willingness to provide informed consent * Inability to comply with study protocol * Use of clopidogrel, or other new anti-platelet therapy, or anticoagulant drugs that cannot be stopped temporarily * Thrombocytopenia 1.3 * Pregnancy

Design outcomes

Primary

Measure	Time frame
-To describe visual qualitative characteristics of CLE, OCT and HHGM images of the alveolar compartment and the airway wall in ILD -To obtain quantitative measurements of ILD by analysis of the CLE, OCT and HHGM imaging of the alveolar compartment (size of the alveoli (um), thickness of the alveolar septum) -To compare the CLE, OCT and HHGM images with pathology results -To identify specific structures and cells (i.e. collagen fibres, elastin, inflammatory cells) on HHGM images of lung tissue -To identify specific structures and cells (i.e. collagen fibres, elastin, inflammatory cells) on HHGM images in ILD	—

Measure

Time frame

-To describe visual qualitative characteristics of CLE, OCT and HHGM images of the alveolar compartment and the airway wall in ILD -To obtain quantitative measurements of ILD by analysis of the CLE, OCT and HHGM imaging of the alveolar compartment (size of the alveoli (um), thickness of the alveolar septum) -To compare the CLE, OCT and HHGM images with pathology results -To identify specific structures and cells (i.e. collagen fibres, elastin, inflammatory cells) on HHGM images of lung tissue -To identify specific structures and cells (i.e. collagen fibres, elastin, inflammatory cells) on HHGM images in ILD

—

Secondary

Measure	Time frame
-To create an image atlas with pOCT, pCLE and HHGM images of the airway wall and alveolar compartment in ILD -Assessing procedure-related adverse events of pCLE and pOCT -Assessing technical feasibility of pCLE, pOCT and HHGM -To assess the timeframe that is necessary for adequate HHGM images of lung tissue in ILD	—

Countries

Netherlands

Outcome results