A study of a non-invasive measurement method for idiopathic pulmonary fibrosis patients. The predictive value of the IOS for the degree of fibrosis compared to the lung function test.

A study of a non-invasive measurement method for idiopathic pulmonary fibrosis patients. The predictive value of the IOS for the degree of fibrosis compared to the lung function test. - IOS IPF study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON55805

Enrollment

120

Registered

2019-04-04

Start date

2021-01-04

Completion date

Unknown

Last updated

2025-12-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Idiopathic pulmonary fibrosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Diagnosed UIP based on the HRCT (UIP pattern or consistency UIP) with fibrosis score> 4 point. Age 18 and older

Exclusion criteria

Exclusion criteria: Other ILD / pulmonary fibrosis, lung carcinoma and other systemic diseases. Patients who can not well perform pumonary function test.

Design outcomes

Primary

Measure	Time frame
Primary Objectives: 1. Does IOS correlate with the degree of fibrosis on the HRCT scan in patients with IPF? - Which IOS parameter correlates best with the degree of fibrosis?	—

Secondary

Measure	Time frame
Secondary Objectives: 1. Is IOS as suitable as the CPI (= conventional spirometry + diffusion) to determine the degree of fibrosis in patients with IPF? - Correlation CPI / HRCT vs correlation IOS / HRCT (comparable or IOS better?) - Our correlation CPI / HRCT corresponding to the r = 0.71 obtained from Wells et al. 2. Does exercise effects the IOS measurement? - IOS before and after conventional lung functions tests. 3. How does the patient experience the IOS measurement? - BORG score + questionnaire	—

Measure

Time frame

Secondary Objectives: 1. Is IOS as suitable as the CPI (= conventional spirometry + diffusion) to determine the degree of fibrosis in patients with IPF? - Correlation CPI / HRCT vs correlation IOS / HRCT (comparable or IOS better?) - Our correlation CPI / HRCT corresponding to the r = 0.71 obtained from Wells et al. 2. Does exercise effects the IOS measurement? - IOS before and after conventional lung functions tests. 3. How does the patient experience the IOS measurement? - BORG score + questionnaire

—

Countries

Netherlands

Outcome results