Long-term outcomes of pulmonary function in HIV-infected patients with a history of Pneumocystis jirovecii pneumonia

Long-term outcomes of pulmonary function in HIV-infected patients with a history of Pneumocystis jirovecii pneumonia - Pulmonary function after PJP in HIV

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON55803

Enrollment

100

Registered

2020-05-11

Start date

2020-12-16

Completion date

Unknown

Last updated

2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

gas transport disorder in the lungs Pneumocystis Jirovecii Pneumonia

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: HIV-infected patients with and without a history of Pneumocystis Jirovecii Pneumonia

Exclusion criteria

Exclusion criteria: * Active pulmonary infection or cardiac decompensation at the moment of pulmonary function testing * Chronic condition which could influence the pulmonary function testing * Unexplained dyspnoea, tachypnoea or other acute respiratory complaints at the moment of pulmonary function testing (

Design outcomes

Primary

Measure	Time frame
The prevalence of abnormalities in pulmonary function testing like obstructive or restrictive lung disease and CO diffusion impairment. The following parameters will be assessed: Vital capacity, Forced Expiratory Volume in 1 second (FEV1) and carbon-dioxide diffusion capacity.	—

Secondary

Measure	Time frame
1. to establish if the prevalence of obstructive ventilatory disorder in HIV infected patients with a history of PJP is significantly higher than in the HIV positive matched controls; 2. to establish if the prevalence of restrictive ventilatory disorder in HIV infected patients with a history of PJP is significantly higher than in the HIV positive matched controls; 3. to establish if there is relation between diminishing of de pulmonary diffusion capacity and the self-reported pulmonary complaints; 4. to establish if the self-reported pulmonary complaints are more prevalent in the group of HIV patients with history of PJP compared to matched controls.	—

Measure

Time frame

1. to establish if the prevalence of obstructive ventilatory disorder in HIV infected patients with a history of PJP is significantly higher than in the HIV positive matched controls; 2. to establish if the prevalence of restrictive ventilatory disorder in HIV infected patients with a history of PJP is significantly higher than in the HIV positive matched controls; 3. to establish if there is relation between diminishing of de pulmonary diffusion capacity and the self-reported pulmonary complaints; 4. to establish if the self-reported pulmonary complaints are more prevalent in the group of HIV patients with history of PJP compared to matched controls.

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Countries

Netherlands

Outcome results