cognitieve stoornissen Brain metastases brain tumor
Conditions
Interventions
Patients in the WBRT group will receive 4 Gy x 5 fractions in one week, which
is a commonly utilized treatment schedule according to Dutch guidelines.
SRS will be performed with a Leksell Gamma Knif
Sponsors
Sint Elisabeth Ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Contrast enhanced volumetric MRI-scan showing 11-20 newly diagnosed BM with a total tumor volume 3 mm from optic apparatus* • Patient age >= 18 years* • Karnofsky Performance Status >= 70, WHO performance status
Exclusion criteria
Exclusion criteria: • No prior histologic confirmation of malignancy • Primary brain tumor, lymphoma, small cell lung cancer, leukemia, or meningeal disease • Progressive, symptomatic systemic disease without further treatment options • Prior brain radiation or surgical resection of BM • Additional history of a significant neurological or psychiatric disorder • Participation in a concurrent study in which neuropsychological testing and/or health-related QOL assessments are involved • Patients unable to complete test battery and/or study questionnaires due to any of the following reasons: lack of basic proficiency in Dutch, IQ below 85, severe aphasia, or paralysis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| • Cognitive functioning as assessed with a battery of neuropsychological tests: The revised Hopkins Verbal Learning Test (HVLT-R), WAIS Digit Span and Digit Symbol, TMT A and B, COWA, and Grooved Pegboard | — |
Secondary
| Measure | Time frame |
|---|---|
| • Fatigue (MFI) • Health related QOL (FACT-BR) • Depression and anxiety (HADS) • Overall Survival • Local and distant tumor control | — |
Countries
Netherlands
Outcome results
None listed