Intracranial aneurysm
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age between 20 and 70 years - At least one first degree relative with an unruptured intracranial aneurysm identified by MRA, CTA or conventional angiography
Exclusion criteria
Exclusion criteria: - People who do not speak Dutch well enough to give informed consent - Any first degree relative with an aneurysmal subarachnoid hemorrhage - A history of an aneurysmal subarachnoid hemorrhage and/or unruptured intracranial aneurysm - A history of polycystic kidney disease, Ehlers-Danlos, or fibromuscular dysplasia - Relative contraindication(s) for MRA, e.g. pregnancy, an internal metal device such as a pacemaker, or claustrophobia - A serious condition that would interfere with the treatment of an UIA, e.g. severe comorbidity or reduced life expectancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective 1) - the prevalence of UIA in persons with >=1 FDR with an UIA Objective 2) - the prevalence of potential risk factors for UIA development in persons with >=1 FDR with an UIA Objective 3) - the prevalence of UIA in persons with >=1 FDR with an UIA | — |
Secondary
| Measure | Time frame |
|---|---|
| Objective 1) - costs of screening for and preventive treatment of UIA - clinical outcome after preventive treatment of an UIA identified with screening - decision model studying cost-effectiveness expressed in costs per QALY Objective 2) - prediction model of risk of UIA in persons with >=1 FDR with an UIA Objective 3) - correlation of imaging markers on 3T and 7T MRA and biopsy findings of the UIA wall | — |
Countries
Netherlands
Outcome results
None listed