AVM braintumor glioma vascular abnormality
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a subject must meet the following criteria: - Age > 18 years - Mentally competent, AND EITHER • Undergoing awake craniotomy surgery for the indication of tumor removal with ESM already planned in the removal of their tumors OR • Undergoing non-awake craniotomy surgery for the indication of tumor removal OR • Undergoing non-awake craniotomy surgery for the indication of AVM-removal
Exclusion criteria
Exclusion criteria: - Depression or an anxiety disorder - Any contra-indication for contrast media Sonovue (Bracco International bv, Amsterdam): known allergy to Polyethylene Glycol or PEG (macrogol) in particular, or to PEG-containing products such as certain bowel preps for colonoscopy or laxatives. - Pregnant and/or lactating women. - Not able to provide written Informed Consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the potential ability of fUS to discriminate between functional and non-functional brain areas using task-specific brain-activity during an awake neurosurgical procedure. | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess the potential use of fUS as a means to discriminate between healthy and pathological tissue (tumor and AVMs) using CBV and/or CEUS CBV measurements to visualize vascularization differences in these tissues during both awake (tumor) and non-awake (tumor and AVM) neurosurgical procedures. | — |
Countries
Netherlands
Outcome results
None listed