Mental functioning, brain Tryptophan availability and affect; the role of the immune system

Mental functioning, brain Tryptophan availability and affect; the role of the immune system - Mental functioning; the role of the immune system

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON55728

Enrollment

Registered

2018-12-31

Start date

2019-03-01

Completion date

Unknown

Last updated

2024-04-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

inflammatory bowel disease irritable bowel syndrome

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Officially diagnosed gastrointestinal disease: IBD or IBS (no inclusion criterion for control group) - Aged between 18- 60 years - Normal BMI (18.5- 25) - Willing and able to give written informed consent - Good understanding of the Dutch language The control group will be matched as closely as possible with the patient group on gender and age

Exclusion criteria

Exclusion criteria: - Indications of acute or chronic disease or psychiatric disorder (other than a chronic gastrointestinal disease) at study entry - Symptoms of a cold / fever / the flu at study entry - Use of medication, apart from contraceptives- especially medications that affect the dependent variable - Pregnancy in the last 6 months / breastfeeding - Known excessive alcohol or drugs use (>15 week) - Smoking

Design outcomes

Primary

Measure	Time frame
The main study parameter consists of variations in plasma TRP/LNAA ratio (indicator of brain TRP availability).	—

Secondary

Measure	Time frame
Secondary parameters are pre-post changes in physiological indices of stress and/ or negative affectivity (cortisol), inflammatory reactivity and indicators of subjective stress/ negative affectivity (mood, negative attention bias).	—

Countries

Netherlands

Outcome results