Primary Immunodeficiencies: immunological and genetic background in relation to clinical complications

Primary Immunodeficiencies: immunological and genetic background in relation to clinical complications - Research into causes and disease course of primary immunodeficiencies

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON55725

Enrollment

1500

Registered

2013-06-19

Start date

2013-08-22

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

immune disorders primary immune deficiencies

Interventions

None listed

Eligibility

Age

2 Years to 99 Years

Inclusion criteria

Inclusion criteria: Patients: a diagnosis of a clinically relevant primary immunodeficiency or a strong suspicion of a diagnosis of primary immunodeficiency Healthy controls: healthy family or household members and/or friends of patients Both groups: informed consent

Exclusion criteria

Exclusion criteria: No consent

Design outcomes

Primary

Measure	Time frame
Ad 1. prospective follow up study. - Survival data - Occurrence of complications, predominantly in the pulmonary, gastro intestinal, hematological tracts, as well as the occurrence of malignancies - These data will be related to clinical and laboratory phenotype Ad 2. improved diagnostics. - Genetic and associated functional defects causative of primary immunodeficiencies.	—

Secondary

Measure	Time frame
Ad 1. prospective follow up study. - Quality of life parameters - Enhanced understanding of the healthy (mucosal) immune system Ad 2. improved diagnostics. - No secondary study outcome parameters.	—

Countries

Netherlands

Outcome results