Pulmonary arterial hypertension
Conditions
Interventions
None listed
Sponsors
VU medisch centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Aim 1: BMP10 secretion by right atrial cardiomyocytes Inclusion criteria patients: - Patients with chronic thrombo-embolic pulmonary hypertension (CTEPH) - Undergoing pulmonary endarterectomy, Inclusion criteria controls: - Patients undergoing cardiac surgery and put on the heart-lung machine, Aim 2: BMP10 release as a bio-assay of right heart failure, Inclusion criteria patients: - Idiopathic PAH (Invasively assessed mean pulmonary artery pressure >25 mmHg, pulmonary artery wedge pressure 18 years, Inclusion criteria controls: - Age >18 years - Age and sex-matched to patients - We will include 10 subjects with a BMPR2 mutation without Pulmonary Hypertension
Exclusion criteria
Exclusion criteria: Aim 1: BMP10 secretion by right atrial cardiomyocytes, Exclusion criteria patients: - Age 42 mm (base))(13) - Tricuspid valve replacement or tricuspid annuloplasty - Dilated right atrium or RA dysfunction (e.g. related to atrial fibrillation, congenital abnormalities; cut-off values: area > 18 cm2) - Age 25 mmHg) - Increased pulmonary artery wedge pressure (>15 mmHg) - Tricuspid valve dysfunction - RV dysfunction - Dilated right atrium or RA dysfunction (e.g. related to atrial fibrillation, congenital abnormalities) - Previous cardiac surgery - Age
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| BMP10 levels measured in bloodsamples and conditioned medium of right atrial cardiomyocytes | — |
Secondary
| Measure | Time frame |
|---|---|
| * BMP10 activity plasma vs. serum * Importance of location of the blood sampling (right atrium vs. venous puncture) on BMP10 activity | — |
Countries
Netherlands
Outcome results
None listed