dopamine psychosis
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: * The participant understands the study and is able to provide written informed consent * Must be between the ages of 18-60 * Sufficient command of the Dutch language * Must have a diagnosis of schizophrenia, schizoaffective disorder, schizophreniform disorder, or those classified as Other Specified Schizophrenia Spectrum and Other Psychotic Disorder * Be mentally competent, as determined by their treating physician * The participant has had a first episode of psychosis and uses antipsychotic medication at the start of the HAMLETT study * The participant is about to discontinue antipsychotic medication * Psychotic symptoms are in remission for 3-6 months * HAMLETT is the only medical-scientific medication study in which the patient participates
Exclusion criteria
Exclusion criteria: * Presence of a neurological disorder * Visual or hearing problems that cannot be corrected * Participation in a scientific research study during the past year involving radiation * the refusal to be informed (by notifying the participant*s physician) of structural brain abnormalities that could be detected during the experiment * MR incompatible implants in the body * Risk of having metal particles in the eyes * Tattoo*s containing red pigments that form a safety risk * Alcohol or substance abuse in the past 6 months * Insufficient knowledge of the Dutch language * Inability to undergo cognitive testing * Use of antipsychotic medication * dangerous or harmful behaviour (i.e. behaviour with a risk of severe physical injury, or actual physical injury inflicted, to self or others) occurred during the psychosis * Coercive treatment (based on a judicial ruling)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is be the binding potential of [11C]raclopride in the striatum (caudate and putamen). | — |
Secondary
| Measure | Time frame |
|---|---|
| n.a. | — |
Countries
Netherlands
Outcome results
None listed