Migraine
Conditions
Interventions
None listed
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Migraine with/ without aura or chronic migraine according to IHS / ICHD-III-beta criteria - Patients have to experience active migraine, which is defined for this study as at least one migraine attack per month on average in the past 6 months. - Age 18 years or older
Exclusion criteria
Exclusion criteria: General exclusion criteria for episodic migraine patients and healthy controls: i) Severe depression and/or panic disorders and/or schizophrenia and/or psychiatric disorders; ii) Epileptic disorders (epilepsy); iii) Severe visual impairment; iv) Only for part 1: use of chronic medication (other than oral contraceptives) in the four weeks preceding the investigation; v) Malignancy in medical history; vi) only for part 2: use of (oral) contraceptives., Episodic migraine patient specific: i) Only for part 1: use of prophylactic medication for migraine in the four weeks preceding the investigation; ii) Inability to differentiate between migraine and other variants of headache; iii) Use of acute migraine or headache drugs on more than 6 days per month., Healthy control specific: i) Suffering from periodic pain attacks or a brain disorder; ii) Personal of family history in first-degree relatives of migraine or trigeminal autonomic cephalgia (TAC); iii) More than one tension-type headache in 3 months., Exclusion criteria for chronic migraine patients: i) Severe depression and/or panic disorders and/or schizophrenia and/or psychiatric disorders; ii) Epileptic disorders (epilepsy); iii) Severe visual impairment; iv) Malignancy in medical history.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| AC-EEG: For the AC-EEG recordings we will use eight to 128 leads, which we will use to measure fluctuations. Our interpretation is that changes in fluctuations will become slower, resulting in e.g. increased autocorrelation and variance. Phase and amplitude correlations between electrodes will be used as measure of cortical excitability. VEP: Visual evoked potentials (VEPs) are electrical potential differences recorded from the scalp in response to visual stimuli. They represent a mass response of cortical and possibly subcortical visual areas. In this study we will use unpatterned flash stimuli because this is a simple and robust way of visual stimulation that will perturb the visual system. We aim to measure the dynamics from the VEP responses (e.g. timing, amplitude of frequency) to assess the recovery phase of the visual system after perturbation to its original state. We expect that the time the visual system needs to recover to its original state is a measure of resilience of the system. | — |
Countries
Netherlands
Outcome results
None listed