long QT syndrome LQTS
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Inclusion criteria
Inclusion criteria: * The mother must be living in The Netherlands. * The mother is between 18 and 40 years of age. * The mother should be pregnant and have had standard obstetric care without abnormalities
Exclusion criteria
Exclusion criteria: * Maternal medical history of conditions that are at risk for affecting the foetus (i.e pregestational diabetes, epilepsy, HIV, hepatitis B) * Maternal use of medication that affects the QTc-interval (https://crediblemeds.org/pdftemp/pdf/CombinedList.pdf) * Foetuses of consanguineous parents * Foetuses with congenital heart disease, chromosomal syndromes, cephalic disorders * Maternal cigarette or alcohol usage during pregnancy * Maternal obesity before pregnancy (BMI * 30) * Abnormalities on the previous foetal ultrasound.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The LVIRT and the myocardial contraction duration will be measured using respectively echocardiographic Doppler tracings and cTDI at a foetal age around 20, 28 and 30 weeks* gestation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Other mechanical foetal echocardiographic parameters at 20, 28 en 30 weeks' gestation. | — |
Countries
Netherlands
Outcome results
None listed